Adjuvant Chemotherapy
Information
- Drug Name
- Adjuvant Chemotherapy
- Description
- Entry(CIViC)
- 2
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| lung non-small cell carcinoma | TP53 DELETERIOUS MUTATION TP53 DELETERIOUS MUTATION | B |
Predictive
|
Does Not Support
|
Sensitivity/Response | Somatic | 2 | 26899019 | Detail |
| lung non-small cell carcinoma | TP53 WILD TYPE TP53 WILD TYPE | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 26899019 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Pooled analysis of TP53 mutations (exons 5-8) from... | TP53 | TP53 DELETERIOUS MUTATION TP53 DELETERIOUS MUTATION | Sensitivity | false | CIViC Evidence | detail |
| Pooled analysis of TP53 mutations (exons 5-8) from... | TP53 | TP53 WILD TYPE TP53 WILD TYPE | Sensitivity | true | CIViC Evidence | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02676349 | Active, not recruiting | Phase 2 | Neoadjuvant mFolfirinox With or Without Preoperative Concomitant Chemoradiotherapy in Patients With Borderline Resectable Pancreatic Carcinoma (PANDAS-PRODIGE 44) | October 13, 2016 | October 2027 |
| NCT02124421 | Active, not recruiting | Phase 2 | HOT: HIPEC in Ovarian Cancer as Initial Treatment | April 2014 | April 2028 |
| NCT01137123 | Completed | Phase 3 | Improve the Treatment of Thoracic Esophageal Cancer | April 2010 | December 2020 |
| NCT00675259 | Completed | Phase 2 | Phase II NCT (Neoadjuvant Chemotherapy) w/ Weekly Abraxane in Combination With Carboplatin & Bevacizumab in Breast Cancer | July 2008 | March 2014 |
| NCT06299930 | Completed | Locoregional Recurrence After Neoadjuvant Versus Adjuvant Chemotherapy | April 22, 2022 | September 12, 2023 | |
| NCT02249013 | Completed | Phase 2 | Short-course HIPEC in Advanced Epithelial Ovarian Cancer | February 2015 | February 23, 2021 |
| NCT02662504 | Completed | Phase 2 | Intrapleural Photodynamic Therapy in a Multimodal Treatment for Patients With Malignant Pleural Mesothelioma | January 16, 2016 | March 13, 2018 |
| NCT04889820 | Not yet recruiting | N/A | Outcome of Neoadjuvant Chemotherapy for Obstructive Colon Cancer | November 1, 2021 | October 31, 2027 |
| NCT06435767 | Recruiting | Quantitative Nodal Burden as a Determinant Identifying Ampullary Adenocarcinoma Patients Benefiting From Adjuvant Chemotherapy | January 1, 2024 | January 1, 2026 | |
| NCT01815853 | Recruiting | Phase 3 | Neoadjuvant Chemoradiotherapy vs. Chemotherapy With Radical Gastrectomy and Adjuvant Chemotherapy for Advanced Gastric Cancer | June 2013 | December 2025 |
| NCT01817192 | Recruiting | N/A | Adjuvant Chemotherapy in Patients With Intermediate or High Risk Stage I or Stage IIA Non-squamous Non-Small Cell Lung Cancer | September 11, 2020 | May 15, 2025 |
| NCT03673072 | Recruiting | Phase 3 | Neoadjuvant Chemotherapy With Gemcitabine Plus Cisplatin Followed by Radical Liver Resection Versus Immediate Radical Liver Resection Alone With or Without Adjuvant Chemotherapy in Incidentally Detected Gallbladder Carcinoma After Simple Cholecystectomy or in Front of Radical Resection of BTC | July 1, 2019 | November 2024 |
| NCT03748485 | Recruiting | N/A | Adjuvant Chemotherapy in Clinical Local Advanced CRC Following Preoperational Therapies and pT0-3N0M0 Diagnosis | April 30, 2019 | December 30, 2027 |
| NCT03789682 | Recruiting | CD155 in Bladder Cancer | January 1, 2018 | January 1, 2028 | |
| NCT03973008 | Recruiting | Phase 3 | Adujvant CT+CRT vs Adujvant CT After D2 Resection for Locally Advanced Proximal Gastric Adenocarcinoma | March 11, 2019 | May 31, 2025 |
| NCT04063527 | Recruiting | Phase 3 | Phase III Trial of Stage I Ovarian Cancer After Surgery | July 20, 2012 | February 1, 2030 |
| NCT04308837 | Recruiting | Phase 2 | A Phase II Trial of Neoadjuvant Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) With Chemoradiation | December 3, 2018 | August 2025 |
| NCT04595929 | Recruiting | N/A | Oncological Benefits of Pressured Intraperitoneal Aerosol Chemotherapy (PIPAC) in Patients With T3-4 Gastric Cancer Cyt- | February 10, 2020 | January 10, 2029 |
| NCT04664504 | Recruiting | Phase 2 | A Prospective Phase II Study of Individualized Neoadjuvant Chemoradiotherapy for Rectal Cancer Based on Recurrence Risk | December 1, 2020 | December 1, 2025 |
| NCT04733820 | Recruiting | Phase 3 | Clinical Efficacy of Adjuvant Chemotherapy in Patients With Locally Advanced Cervical Cancer Who Did Not Meet the NCCN Guidelines for Adjuvant Treatment After NACT Combined With Surgery | February 1, 2021 | February 1, 2028 |
| NCT04755907 | Recruiting | 3D Bioprinted Models for Predicting Chemotherapy Response in Colorectal Cancer With/Without Liver Metastases | March 1, 2021 | December 31, 2023 | |
| NCT05194878 | Recruiting | Phase 3 | Neoadjuvant FOLFOXIRI Versus Immediate Surgery for Stage II and III Colon Cancers | December 1, 2021 | December 2026 |
| NCT05496491 | Recruiting | N/A | Neoadjuvant Chemoradiotherapy and Consolidation Chemotherapy for Rectal Cancer: A Randomized Controlled Trial | August 30, 2022 | August 30, 2025 |
| NCT05595408 | Recruiting | Circulating Tumour DNA and Urine Tumor DNA Detection of Minimal Residual Disease in Locally Advanced Upper Tract Urothelial Carcinoma With Radical Nephroureterectomy: A Cohort Study | February 1, 2022 | December 31, 2024 | |
| NCT06208436 | Recruiting | The Survival Outcome of Adjuvant Chemotherapy for Stage I Pancreatic Cancer | October 7, 2023 | February 28, 2024 | |
| NCT06223763 | Recruiting | SUROVA - Surgery in Ovarian Cancer, Comparing Primary and Interval Cytoreductive Surgery | January 1, 2024 | June 1, 2024 | |
| NCT06427447 | Recruiting | Phase 3 | Adjuvant Chemoradiotherapy Versus Chemotherapy for Pancreatic Cancer (ADJUPANC) | May 12, 2024 | June 30, 2029 |
| NCT05456165 | Terminated | Phase 2 | Study of an Individualized Vaccine Targeting Neoantigens in Combination With Immune Checkpoint Blockade for Patients With Colon Cancer | May 19, 2022 | September 1, 2022 |
| NCT00216086 | Terminated | Phase 2 | Capecitabine + Irinotecan Followed by Combined Modality Capecitabine and Radiation in Locally Advanced Rectal Cancer | May 2005 | May 2008 |
| NCT02404753 | Unknown status | Phase 2 | A Comparison of Laparoscopic With Open Distal Gastrectomy in Advanced Gastric Cancer After Neoadjuvant Chemotherapy | April 2015 | November 25, 2022 |
| NCT02280278 | Unknown status | Phase 3 | Cytokine-induced Killer Cell Immunotherapy for Surgical Resected Stage III Colorectal Cancer Patients After Chemotherapy | October 2014 | |
| NCT02738697 | Unknown status | Phase 3 | Adjuvant Chemotherapy With FOLFOX in HCC Patients After Resection | January 2016 | December 2021 |
| NCT02959879 | Unknown status | Phase 2 | Neo-adjuvant FOLF(IRIN)OX for Resectable Pancreatic Adenocarcinoma | March 1, 2017 | December 2021 |
| NCT02960061 | Unknown status | Phase 3 | Perioperative Chemotherapy Combined With HIPEC for High-risk Advanced Gastric Cancer | November 2016 | December 2019 |
| NCT03177382 | Unknown status | Phase 3 | Total Neoadjuvant Treatment vs. Chemoradiotherapy in Local Advanced Rectal Cancer With High Risk Factors | June 15, 2017 | May 30, 2023 |
| NCT03180177 | Unknown status | Phase 3 | Efficacy of HIPEC as NACT and Postoperative Chemotherapy in the Treatment of Advanced-Stage Epithelial Ovarian Cancer | March 1, 2018 | July 1, 2022 |
| NCT03308591 | Unknown status | Phase 3 | Clinical Efficacy of the Neoadjuvant Chemotherapy for IB2 and IIA2 Stage Cervical Cancer Patients | January 1, 2016 | December 31, 2020 |
| NCT03373058 | Unknown status | Phase 3 | Efficacy of HIPEC in the Treatment of Advanced-Stage Epithelial Ovarian Cancer After Cytoreductive Surgery | October 15, 2019 | July 1, 2023 |
| NCT02193594 | Unknown status | Phase 2/Phase 3 | Preoperative Concurrent Chemoradiotherapy for Locally Advanced Gastroesophageal Junction or Upper Gastric Adenocarcinoma | January 2014 | May 2020 |
| NCT04737551 | Unknown status | Adjuvant Chemoradiation Following Radical Resection of Pancreatic Ductal Adenocarcinoma, a Prospective Cohort Study | January 1, 2020 | December 31, 2023 | |
| NCT04747951 | Unknown status | Phase 4 | Total Neoadjuvant Therapy in Rectal Cancer Treatment | October 30, 2020 | November 1, 2023 |
| NCT01047969 | Unknown status | Phase 2 | Avoiding Surgery in Rectal Cancer After Pre-Operative Therapy | June 6, 2006 | June 2019 |
| NCT04198051 | Unknown status | N/A | The Clinical Study of Adjuvant Chemotherapy on Intestinal and Urethral Flora in Patients With Gastric and Colon Cancer | December 20, 2019 | May 1, 2021 |
| NCT02464774 | Unknown status | N/A | Breast-Conserving Therapy in Patients With Triple-Negative Breast Cancer | July 2015 |